The research interest of our laboratory is developing functional hybrid biomaterial solution for implantology, regenerative medicine and specific diseases by means of surface modification, tissue engineering and nanotechnology. Our research lies at the interfaces of fundamental material science, biology and clinical applications at the macro-, micro- and nano- scale level, where basic understanding of biology inspires the development of functional hybrid biomaterials for medical applications. We believe quality work depends on idea, passion and persistence. The students and postdoc fellows who join our group will have opportunities to learn from and work with engineers, biologists and clinicians.
Tissue engineering consists of four categories: scaffold, drug release, cell and signals. In our lab, we focus on optimization of scaffold design and fabrication to mimic the in vivo natural environment, to aid and induce tissue regeneration. In our lab, bioceramics, polymer and composite scaffolds with different composition, geometry structure and shapes are fabricated using different techniques, and their effect on bone cell and bone tissue have been evaluated. 2Currently our research is in the field of controlled biodegradable rate of scaffolds with porous covered polymeric microsphere, thereby achieving a controlled release rate of growth factor and drugs within antibacterial effect. In addition, we are interested in applying the developing biomaterials for specific diseases such as bony birth defects and cancer therapy.
Surface engineering focuses on implant surface chemistry, texture and mechanical properties to improve performance of dental and orthopedic implant devices. In clinical, osseointegration, which is defined as the direct bone-implant contact, is critical for initial fixation and long-term success of endosseous dental and orthopedic implants.1 In our lab, the implant surface chemistry, texture and mechanical properties have been modified via chemical treatment and ion beam sputtering within antibacterial effect. The enhancement of osseointegraion has been evidenced by in vitro cell culture and in vivo animal study.